Massachusetts General Hospital
Harvard Medical School
Massachusetts Institute of Technology
Broad Institute of MIT and Harvard

A SOFTWARE PACKAGE FOR ANALYZING SNAPSHOTS OF DEVELOPMENTAL PROCESSES

Single-cell genomics allows us to profile the diversity of cells along a developmental time course. However, we cannot directly observe cellular trajectories because the measurement process is destructive. WADDINGTON-OT is designed to infer the temporal couplings of a developmental stochastic process from samples collected at various timepoints and to reconstruct developmental trajectories of distinct cell lineages.