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Research. Biological Question Driven + Technological Innovation. 

We are passionate about understanding the players and interactions in complex biological ecosystems and methods to reprogram and engineer cellular and molecular circuits. Our research focuses on 1) developing and optimizing experimental and computational approaches to integrate genomic, epigenomic, spatial, and imaging data, along with CRISPR perturbations and lineage tracing, to decode complex systems in time and space at single-cell resolution; 2) applying these single-cell toolboxes to study immune tolerance in immune-privileged sites and tumor immune evasion. 

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IMAGE-OMICS
NET

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WADDINGTON-OT

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FETOMATERNAL TOLERANCE AND TUMOR EVASION

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STEM CELLS

TOTIPOTENCY

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REPROGRAMMING